Frontiers | Epidemiology, Drug Susceptibility, and Clinical …
BackgroundThis study aimed to investigate the Aspergillus species distribution, antifungal sensitivities, clinical characteristics, and risk factors of patients with invasive aspergillosis (IA) in a tertiary teaching hospital in Anhui Province.MethodsIn the present study, 156 Aspergillus isolates were collected from patients admitted to a 2,800 …
Aspergillus
Aspergillus species, which are ubiquitous in distribution, occurring on a wide range of substrata and found in almost all give space environments, are a genus consisting of several hundred highly aerobic mold species, including Aspergillus versicolor, A. fumigatus, A. glaucus, A. nidurans, A. parasiticus, etc. [1–5].
Aspergillus Test Profiles and Mortality in Critically Ill COVID …
We analyzed 219 critically ill COVID-19 cases, including 1 proven, 38 probable, 19 possible CAPA cases, 21 Aspergillus -colonized patients, 7 patients only positive for serum (1,3)-β- d -glucan (BDG), and 133 cases with no evidence of CAPA. Mortality was 53.8% in CAPA patients compared to 24.1% in patients without CAPA ( P …
Symptoms, diagnosis and treatment
Filamentous fungi of the Aspergillus species are ubiquitously found as soil inhabitants. Inhalation of the aerosolized conidia (spores) causes the infection. The clinical spectrum varies from colonization, allergy (e.g., allergic bronchopulmonary aspergillosis), asthma, or aspergilloma (fungal ball) to invasive disease depending on host immune …
Aspergillus Species Causing Invasive Fungal Disease in …
Results. 236 Aspergillus spp. were identified from clinical specimens during the study period. The most frequent species identified were Aspergillus section Fumigati (n = 119), Aspergillus section Flavi (n = 35), Aspergillus terreus (n = 32) and Aspergillus niger (n = 29).Overall, MIC 50/90 values for voriconazole, posaconazole, itraconazole, …
Pathogens | Free Full-Text | Aspergillus Genus and Its Various …
Furthermore, Aspergillus otomycosis can be seen in immunocompromised hosts, after open-cavity mastoidectomy surgery, after the accumulation of epithelial debris in the external auditory canal, and after the use of hearing aids with an occlusive ear mould [36,78]. Many factors encourage infection and changes in the epithelial covering.
Blood Aspergillus PCR: The Good, the Bad, and the Ugly
1.2. The Good. One of the major strengths of blood Aspergillus PCR is its high sensitivity and negative predictive value (NPV) in severely immunocompromised patients with underlying hematological malignancies in settings where antifungal prophylaxis is not used. A 2019 published systematic review highlighted a mean sensitivity and …
Aspergillus Genus and Its Various Human Superficial and …
1. Introduction. Aspergillus species are a large group of common saprophytic moulds which are isolated from soil, air, and plant materials. Aspergillus species can cause a group of superficial and cutaneous mycoses: distal lateral subungual onychomycosis, proximal subungual onychomycosis, otomycosis, and cutaneous …
Aspergillus (Galactomannan) Antigen, Serum
Invasive aspergillosis (IA) is a severe infection that occurs in patients with prolonged neutropenia, following transplantation or in conjunction with aggressive immunosuppressive regimens (eg, prolonged corticosteroid usage, chemotherapy). The incidence of IA is reported to vary from 5% to 20% depending on the patient population.
Aspergilloma
Continuing Education Activity. An aspergilloma is a fungus ball or mycetoma composed of Aspergillus hyphae along with cellular debris and mucus. It is a noninvasive type of chronic pulmonary aspergillosis. Aspergillus species colonize the preexisting cavity in the lung parenchyma and form a fungus cavity.
Aspergillus spinal epidural abscess: A case report and …
Articles from Journal of Craniovertebral Junction & Spine are provided here courtesy of Wolters Kluwer -- Medknow Publications. Aspergillus spinal epidural abscess (ASEA) is a rare entity that may mimic Pott's paraplegia as it commonly affects immunocompromised patients. We present one institutional case of ASEA with …
Aspergillosis
These drugs are the standard treatment for invasive pulmonary aspergillosis. The most effective treatment is a newer antifungal drug, voriconazole (Vfend). Amphotericin B is another option. All antifungal drugs can have serious side effects, including kidney and liver damage. Interactions between antifungal drugs and other medications are also ...
The clinical spectrum of pulmonary aspergillosis | Thorax
The clinical presentation of Aspergillus lung disease is determined by the interaction between fungus and host. Invasive aspergillosis develops in severely immunocompromised patients, including those with neutropenia, and increasingly in the non-neutropenic host, including lung transplant recipients, the critically ill patients and patients on steroids. A …
Practice Guidelines for the Diagnosis and Management of
Aspergillus species continue to be an important cause of life-threatening infection in immunocompromised patients. This at-risk population is comprised of patients with prolonged neutropenia, allogeneic hematopoietic stem cell transplant (HSCT), solid organ transplant (SOT), inherited or acquired immunodeficiencies, corticosteroid use, …
Clinical Characteristics and Treatment Outcomes of …
Aspergillus nodules represent a subtype of chronic pulmonary aspergillosis, but details on their characteristics and outcomes are limited. We evaluated 80 patients with pathologically confirmed Aspergillus nodules between January 2009 and December 2016. The median age of the patients was 59 years, and 46 (58%) were women. Seventy-three …
Aspergillus species intrinsically resistant to antifungal agents
Abstract. Polyphasic taxonomy has had a major impact on the species concept of the genus Aspergillus.New sibling species have been described that exhibit in vitro susceptibility profiles that differ significantly from that of Aspergillus fumigatus.While acquired resistance is an emerging problem in A. fumigatus, non-A. fumigatus …
Aspergillosis: Types, Causes, Symptoms, Diagnosis
What causes aspergillosis? Many different species of the fungi Aspergillus cause aspergillosis.A. fumigatus is the most common cause.. Aspergillus lives in the environment around us, so we can easily breathe it in. Most people's bodies eliminate Aspergillus fungus without getting sick. But certain conditions, like a weakened immune …
Aspergillosis: Symptoms, Causes, Types, and Treatment
Allergic pulmonary aspergillosis: People with underlying lung problems like asthma and cystic fibrosis may be at high risk of developing an allergic reaction to the aspergillus fungus. Common symptoms include wheezing, shortness of breath, and malaise. Chronic pulmonary aspergillosis: In some cases, aspergillus infection lays …
Use of X-ray irradiation for inactivation of Aspergillus in …
In this study, we examined the potential of X-ray irradiation for inactivation of cannabis flower contaminated with any of the four pathogenic species of Aspergillus. We determined that X-ray irradiation at a dose of 2.5 kGy is capable of rendering Aspergillus cells non-viable at low (10 2 spores/g dried flower), medium (10 3 spores/g dried ...
Potential value of serum Aspergillus IgG antibody detection …
Results. The positive rate of the G test, Aspergillus IgG antibody detection and the GM test also showed notable differences among the IPA, CPA, community-acquired bacterial pneumonia and healthy groups (P = 0.006, P < 0.001 and P = 0.217, respectively).Only the positive rate of the GM test showed a significant difference …
Emerging Aspergillus Species Almost Exclusively Associated …
A black arrow indicates 5 well-known pathogenic species of Aspergillus, and a red arrow identifies other emerging aspergilli reported primarily in patients with underlying primary immunodeficiency. Thick branches indicate >95% bootstrap support; numbers above nodes are Bayesian probabilities greater than 0.90.
Aspergillus serology: Have we arrived yet?
Chronic pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Chronic pulmonary aspergillosis (CPA) is estimated to affect 3 million persons worldwide. 13,Aspergillus -specific IgG is a key component in CPA diagnosis. CPA usually occurs in patients with underlying pulmonary disease, and the lesion usually progresses latently.
Aspergillosis
This allows aspergillus to take hold, invading the lungs and, in the most serious cases, other parts of the body. Aspergillosis is not contagious from person to person. Risk factors. Your risk of developing aspergillosis depends on your overall health and the extent of your exposure to mold. In general, these factors make you more vulnerable to ...